Symbol
Name
ID

Tcirg1
T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
MGI:1350931

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Pancytopenia	Anemia	Thrombocytopenia	Splenomegaly
Disease(s) Associated with TCIRG1
autosomal recessive osteopetrosis 1

Mouse Phenotypes

thymus atrophy

extramedullary hematopoiesis

increased megakaryocyte cell number

increased granulocyte number

decreased B cell number

decreased T cell number

decreased lymphocyte cell number

increased osteoclast cell number

abnormal osteoclast morphology

abnormal spleen morphology

abnormal spleen red pulp morphology

abnormal spleen white pulp morphology

decreased spleen B cell follicle size

abnormal spleen B cell corona morphology

increased spleen germinal center number

abnormal spleen periarteriolar lymphoid sheath morphology

increased IgG1 level

increased IgG2a level

increased IgM level

increased immunoglobulin level

abnormal macrophage physiology

abnormal osteoclast physiology

Availability

Mouse Genotype

Tcirg1^oc/Tcirg1^oc

Tcirg1^tm1.2Ywd/Tcirg1^tm1.2Ywd

Tcirg1^tm1Utku/Tcirg1^tm1Utku

Tcirg1^tm1Ypl/Tcirg1^tm1Ypl

Tcirg1^M1Jeau/Tcirg1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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